Luna Innovations Receives Funding for Brain Cancer Diagnostic Agent Using Nanotechnology

 Luna Innovations Incorporated (NASDAQ: LUNA) announces an award from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) to improve the detection and diagnosis of brain tumors.  Under this program, Luna will adapt its exclusive contrast agent technology using carbon nanospheres to produce an improved magnetic resonance imaging (MRI) agent.  This next-generation contrast agent will be designed to enhance tumor imaging and advance the diagnosis and treatment of this disease by directing nanomolecules to seek out specific biological targets, such as a glioblastoma tumor, one specific form of brain cancer.

MRI is critical for the diagnosis and evaluation of many forms of brain and other cancers.  “Primary malignant brain tumors cause 13,000 deaths in the United States annually and survival rates following therapeutic intervention are among the lowest compared to other cancers,” stated Robert Lenk, President of Luna’s nanoWorks division. “The work we are doing with NIH allows us the opportunity to build on our existing contrast agent platform of carbon nanomedicines and ultimately improve the detection and diagnosis of these high risk brain tumors.”

Luna’s imaging technology can be modified to direct it to accumulate at specific targets. Luna’s MRI contrast agent prototype is based on a modification of its TRIMETASPHERE® carbon nanomaterial known as the HYDROCHALARONE™, which has shown promise to significantly enhance relaxivity, a property that provides for better imaging; is extremely stable; is water soluble; and has the potential to be modified to clear from the bloodstream quickly or slowly, depending on the specific application. “Luna’s Hydrochalarone technology platform can be modified to produce targeted contrast agents, which selectively highlight the tumor cells. Our hope is that our novel approach will provide better resolution to radiologists, who in turn, will improve patient outcomes,” said Kent Murphy, Chairman and CEO of Luna Innovations Incorporated.

Last November, Luna announced its first grant with the NIH using this carbon nanotechnology platform to improve the identification of coronary artery disease. Under this program, Luna proposed to develop a diagnostic agent that would allow the use of MRI, potentially providing a noninvasive measure to evaluate plaque in the arteries without the use of ionizing radiation and catheters.




Siemens 7 tesla mri scanner installed, ready for clinical use?




It will be the only magnetic resonance tomograph of the modern 7 tesla generation in the world, in which a metrology institute is also involved. Magnetic resonance tomographs, which use a magnetic field of 7 tesla, have not yet been in operation in hospitals and clinics, but have solely served research. For the first time in the world, cardiovascular research carried out on such a device is now also to play an important role. The magnetic resonance tomograph costing approximately seven million Euros and weighing 35 tonnes was delivered to its new location, the Experimental and Clinical Research Center (ECRC) of the Max Delbrück Center (MDC) for Molecular Medicine in Berlin-Buch on 11th September. In contrast to the 1.5 and 3 tesla devices which have largely been the norm to date, its higher magnetic field will provide sharper images and better insights into the smallest structures of the human body. The aim is to detect the risk or commencement of an illness at a very early stage in heart, brain and cancer research. Above all, heart research by magnetic resonance tomography is viewed as very difficult. As such, a demanding task will be waiting for PTB scientists from January 2009, when the device has been fully installed: as the partner dealing with physics and technical issues in the joint project, they are responsible for making the unique potential of this tomograph useful for applications in clinics. The PTB will, moreover, find the ideal conditions to advance its work on patient safety in high-field tomographs and on the development of new concepts in MRT imaging. The other partners in the project, besides the Max Delbrück Center and the PTB, are Siemens, the constructors of the 7 tesla device, and the Charité hospital. The new ultra-high-field MRT equipment of the ECRC has been completed with a 9.4 tesla small animal MRT of the Bruker company which was supplied three weeks ago


Rockhawk plaque removal system

The Peripheral Plaque Excision System for Surgical Use is the latest addition to the SilverHawk® family of products. This advanced endovascular device enables physicians to treat above-the-knee de novo and restenotic calcified and non-calcified lesions located in the native peripheral arteries. The RockHawk is based on our popular SilverHawk® platform and incorporates design changes in the geometry and the material of the cutting blade that significantly reduce the force needed to cut through calcified lesions, potentially resulting in decreased procedure time.

  • The RockHawk system is based on the SilverHawk Peripheral Plaque Excision System first marketed in the US in 2003. 

  • With the product feature advancements, the device now has the ability to excise plaque and calcium above-the-knee.

  • This model incorporates changes in the geometry and the material of the cutter structure to facilitate the break down of complex, hard, calcified lesions that may be resistant to conventional treatment.

  • The RockHawk also features a floating ramp that imparts better suspension to the unique cutter, allowing it to stay engaged against the lesion, similar to the pivot heads of a shaving razor.

  • The flush cleaning mechanism enables quick and easy cleaning of hard substances like calcium from the tip of the device.

Dave’s place in Radiology does it again!

Thanks Dave for compliling a list of some of the Best MRI websites on the Internet. Thanks.

  • Acorn NMR  Acorn NMR Inc.

  • Adelaide MRI Website (Australia) a great MRI site A Home Made Collection of Web Base Resources on MRI Issues.  Prepared By Greg Brown

  • Association of Managers of Magnetic Resonance Laboratories  The AMMRL is a group of individuals who are responsible for the operation of laboratories and instrumentation for magnetic resonance spectroscopy, including nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). Our main goal is to assist one another in providing the best resources possible for research and applications using magnetic resonance spectroscopy, through exchange of information and experience. AMMRL has no formal organizational structure, providing instead an informal means for like-minded individuals to find one other and explore issues of mutual importance. A steering committee is responsible for the operation of the group. Our primary means of interaction are by email, and in a session held at the annual Experimental NMR Conference (ENC). A directory listing of members, including information about instruments owned, also contributes to maintaining this community.

  • Basics of MRI   An online tutorial of the basics of MRI by Joseph P. Hornak, Ph.D.

  • Bill Faulkner’s Home Page  Wm. Faulkner, B.S.,R.T.(R)(MR)(CT) MRI Education and Operations Consulting

  • BioMagResBank  BMRB’s mission is to collect, archive, and disseminate (worldwide in the public domain) the important quantitative data derived from NMR spectroscopic investigations of biological macromolecules. Relevant data are deposited by the scientists who generate them, and in consultation with these scientists, BMRB resolves any problems with the self-consistency and completeness of the deposition. In collaboration with the Protein Data Bank, BMRB provides links between the spectral data and associated atomic coordinates. BMRB works with the user community to develop formats for these data that can be parsed by computers and used for knowledge generation, alone and in conjunction with information from other databases. BMRB’s goal is to empower scientists in their analysis of the structure, dynamics, and chemistry of biological systems and to support further development of the field of biomolecular NMR spectroscopy. Through international collaborations and mirror sites, BMRB endeavors to involve the participation of a wider group of scientists and to enhance its services worldwide.

  • CABM Protein NMR Spectroscopy Laboratory The CABM Structural Bioinformatics Laboratory carries out structure and function studies of gnomically-defined protein targets. The lab uses both NMR and X-ray crystallography, along with computational methods, to address questions emerging from genomic and functional genomic analyses. The lab also develops software to automate structure determination by NMR methods. It is one of the principal nodes of the United States Protein Structure Initiative.

  • Center for MR-guided Therapy, University of Minnesota  The interventional MR suite at the Fairview University Medical Center is a joint venture between Fairview and Philips Medical Systems. The suite was opened in the summer of 1996 and neurosurgical utilization of the system began in earnest in the spring of 1997. Approximately 100 neurosurgical cases per year are now performed in the suite, consisting of brain biopsies, tumor resections, and deep brain stimulator placement.

  • Centre for Magnetic Resonance, University of Queensland  The Centre for Magnetic Resonance (CMR) is a ‘University Centre’ at the University of Queensland. Following a successful collaboration between Griffith University, the Queensland Institute of Technology and the University of Queensland established a research facility for Nuclear Magnetic Resonance (NMR) imaging at the Mater Hospital in the mid-1980s. In 1990, the Centre was established at the St Lucia campus as an inter-institutional research centre, in collaboration with QUT.

  • Clinical Magnetic Resonance Society   Our Mission To promote and support excellence in interpretative skills and technical knowledge of those involved in the evaluation of clinical magnetic resonance imaging and to help maintain professional practice integrity. Our Vision To focus on the advancement of magnetic resonance imaging as a primary diagnostic and health management tool. Our Strategy It is our conviction that the quality of MR interpretation can be advanced by a clinically oriented professional society which provides experience-based credentialing for physicians, quality clinical education for physicians and technologists, as well as supports compliance with professional and technical regulations.

  • CoolMRIstuff  MY website is about Medical cutting edge technology, Medical procedures, cross sectional anatomy, medical conditions, research, Diagnostic tools, and other cool stuff. There is a lot of interesting things on my page for Medical Professionals & the public. Check out the video of a wheelchair stuck to an MRI machine. There are live video feeds for brain surgery. 3d reconstructions of the heart on You tube. links to many medical vendors.

  • Computational Staining of Magnetic Resonance Brain Images, Caltech Computer Graphics Group This page illustrates a small set of techniques for display of magnetic resonance brain images. MRI produces images from within physical objects, with each point in the image consisting of a scalar or vector value. Most of the computational staining work shown here starts from ray MRI scalar or vector data, processes it to produce new vector data, with each element of the vector weighting a color added in to the final output image

  • Fonar Upright MRI added 09/12/2008 17:26  Fonar Corporation, the MRI Specialist™, is the world’s leading developer and manufacturer of MRI scanners. Throughout 25 years of invention, development and production, Fonar has been on the leading edge of innovation in the MRI industry. In 1980, Fonar revolutionized diagnostic imaging though the introduction of the world’s first commercial MRI scanner. Now Fonar has revolutionized diagnostic imaging with its Upright™ MRI, the world’s first MRI that performs Upright™ Imaging and Position Imaging™.

  • Functional MRI Home Page, Massachusetts General Hospital  Welcome to the Functional MRI and Functional Neuroimaging Web server. This home page is currently under construction.

  • Goal-Directed Magnetic Resonance Brain Micro-Imaging, Human Brain Project, Caltech Computer Graphics Group  The central theme of this project is to apply newly emerging computational techniques to in vivo optical and Magnetic Resonance Imaging (MRI) of the developing brain. Teleological modeling is being developed as a method of optimizing data collection and rendering. Hierarchical multi-resolution image matching is being used to meld into a coherent whole the information obtained through different imaging modalities at different spatial and temporal resolutions. We have assembled a diverse group of computational scientists and neuroscientists with a common interest in addressing questions about the formation of elaborate structures and the acquisition of complex function in the developing brain.

  • In vivo MR Spectroscopy, Medical College of Wisconsin  The research programs in the Department of Biophysics are also multidisciplinary in nature and our program has strong associations with researchers in other basic science and clinical departments. There is a history of quality graduate education in the Department of Biophysics at the Medical College of Wisconsin.  Our graduates are successful scientists in universities, leading edge companies, and government agencies.  The size of our program encourages the development of a close working relationship between students and faculty.  In addition, every effort is made to optimize and tailor our training program to meet individual student needs in preparation for successful careers in Biophysics.  Our doctoral program provides diverse research opportunities in two main tracks of study: the Magnetic Resonance Biophysics (MRI) track and the Molecular Biophysics track.  Eligible students should have a strong background in physics, chemistry, engineering, mathematics, or statistics.  The primary objective of our graduate program is to provide students with an academic background and state-of-the-art scientific approaches needed to investigate and solve the important biological and biomedical problems that will be the focus of research in the years to come. B. Kalyanaraman, PhD Chairman and Professor of Biophysics

  • International Society for Magnetic Resonance in Medicine  The International Society for Magnetic Resonance in Medicine is a nonprofit professional association devoted to furthering the development and application of magnetic resonance techniques in medicine and biology. The Society holds annual scientific meetings and sponsors other major educational and scientific workshops

  • Introduction to MRI Welcome to the exciting world of MRI! This is a tutorial that will cover the basic aspects of MRI.

  • Journal of Magnetic Resonance The Journal of Magnetic Resonance presents original papers in the fields of nuclear magnetic resonance, electron spin resonance, and nuclear quadrupole resonance spectroscopy, as well as in related experimental techniques. The subjects covered include the principles underlying these methods; significant experimental results, especially those leading to spectral correlations likely to be of general interest to scientists in these areas; and descriptions of apparatus, experimental techniques, procedures of spectral analysis and interpretation, and computational methods.  The unified format as of 1997 integrates methods, data, and substances of interest to those working with systems of biological or biochemical significance. Together with the results of studies of structure, dynamics, and interactions of biomolecules, as well as analyses comparing results from magnetic resonance methods with those deduced from other techniques, the journal also publishes papers on in vivo imaging methods and localized spectroscopy

  • Magnetic Resonance Centre, University of Nottingham This group develops techniques and hardware for MRI and Magnetic Resonance Spectroscopy (MRS), particularly echo-planar imaging (EPI). It also works on the applications of these techniques, particularly in neuroscience. Most of the group are based in the Sir Peter Mansfield Magnetic Resonance Centre (SPMMRC), which is an annex of the main Physics building.

  • Magnetic Resonance Lab, University of Virginia  The lab consists of four NMR spectrometers, one EPR spectrometer, and several computers for data processing and lab management.

  • MedPix™ MRI Teaching Files  MRI teaching file from MedPix Peer Reviewed Teaching File Cases.

  • MR Angiography  The protocols presented here are our current practice. They were developed on the basis of 10 years experience with thousands of body MR Angiography cases. We are constantly refining and updating these protocols as magnets are updated and new pulse sequences become available. We hope that you find these protocols to be useful. We would appreciate hearing about any problems, insights or suggestions that you may have.

  • MRI Contrast Agents  Although MRI was initially hoped to provide a means of making definitive diagnoses non invasively, we have found that the addition of contrast agents in many cases improves our sensitivity and/or specificity. Paul Lauterbur and his associated were the first to demonstrate the feasibility of using paramagnetic contrast agents to improve tissue discrimination in MRI. I have somewhat arbitrarily grouped this topic into the subjects listed below. If you would like to review the differences between diamagnetic, paramagnetic, super paramagnetic, and ferromagnetic; look over the magnetism section

  • MRI of Hippocampus in Incipient Alzheimer’s Disease, University of Kuopio

  • MRI Safety  The premier information resource for magnetic resonance safety. This web site is the official site of the INSTITUTE FOR MAGNETIC RESONANCE SAFETY, EDUCATION, AND RESEARCH

  • Musculoskeletal and Orthopedic MRI This blog is for educational and informational purposes only. If you are a patient, by using this blog site you understand that there is no physician-patient relationship between you and any authors on this blog. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition. The authors of this blog cannot answer questions about your specific medical condition.

  • National High Magnetic Field Laboratory (NHMFL), Florida State University  The NHMFL develops and operates high magnetic field facilities that scientists use for research in physics, biology, bioengineering, chemistry, geochemistry, biochemistry, materials science, and engineering. It is the only facility of its kind in the United States and one of only nine in the world. It is the largest and highest powered magnet laboratory, outfitted with the world’s most comprehensive assortment of high-performing magnet systems. Many of the unique facilities were designed, developed, and built by the world’s premier magnet engineering and design team of the NHMFL in collaboration with industry.

  • National Magnetic Resonance Facility, Madison  The National Magnetic Resonance Facility at Madison (NMRFAM) is an NIH-funded, Biomedical Technology Research Resource Center located in the Department of Biochemistry at the University of Wisconsin-Madison. Funding comes from the National Center for Research Resources (NCRR) and from user fees. The policy of NMRFAM is to provide state of the art NMR spectrometer facilities to users both locally and nation wide. The NMRFAM Newsletter keeps users up to date on the workings of the facility. Scheduling is done on a monthly basis allowing users easy access to the spectrometers. Where open time slots are available, users can sign up for time, weeks, days or even hours in advance. New users are encouraged to contact NMRFAM to discuss how our facilities can be used to support collaborative or service projects.

  • NMR Center, Massachusetts General Hospital   History: In 1999 Thanassis and Marina Martinos of Athens, Greece presented a gift of $20M to the Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences & Technology (HST) to honor the memory of their daughter Athinoula. The purpose of the gift was the establishment of a biomedical imaging center dedicated to fostering research that would span disciplines from the basic biosciences to clinical investigation to the development and medical application of new technologies. HST invited the Massachusetts General Hospital (MGH) to participate in founding the Athinoula A. Martinos Center for Biomedical Imaging, and a partnership was formed. This partnership united the clinical and imaging expertise and extensive imaging facilities of the existing MGH Nuclear Magnetic Resonance (NMR) Center with HST’s strengths in engineering and basic neuroscience and the resources represented by the Martinos family gift. Hence, the Martinos Center was launched in 2000 under the Directorship of Bruce R. Rosen, MD, PhD, with a faculty of approximately forty investigators and over $23 million in existing biomedical imaging equipment. The Center is located on the MGH research campus in the Charlestown Navy Yard with a satellite facility on the MIT campus.

  • NMR Home Page, University of Cambridge Chemical Laboratories  Welcome to the web pages of the University Chemical Laboratory NMR Section.  Use the buttons in the margin to navigate around the site – these are available from all the NMR pages. Alternatively, use the links within the text as they appear.  The NMR section in the Chemistry Department, is responsible for the upkeep and maintenance of 10 high field superconducting magnet systems, and their associated hardware. We also run the NMR analytical service, for research workers within the department, and have access to all these machines. This enables us to offer a wide variety of experiments at various field strengths. More information can be found on the NMR Systems page.

  • NMR Home Page, University of Potsdam

  • NMR Newsletter The Most Accurate Links on the Web

  • NMR Spectroscopy, Imperial College of Science, Technology and Medicine

  • NMR Spectroscopy, NIH, U.S.   STRUCTURAL BIOLOGY AT NIH NMR Spectroscopy

  • NMR, Widener University The ideas for this site originated at an NSF Faculty Enhancement Workshop, Concepts in NMR, in the summer of 1994. I originally developed this site for a presentation at the 1995 National Science Foundation NMR Summer Workshop at the University of Rhode Island while I was participating in a second workshop on 2-D NMR.

  • Nuclear Magnetic Resonance Laboratory, University of Ferrara   This is located the Chemistry Department of the University of Ferrara. Although I am in the research group of organic synthesis directed by Prof. Alessandro Dondoni, we perform NMR experiments for other researchers of our Department as well other Departments of the University.

  • Overseas Chinese Magnetic Resonance Association (OCMRA)  The following are the temporal organizers of Overseas Chinese Magnetic Resonance Association (OCMRA): Gu,Titan Ph.D., Glaxo SmithKline Pharm., Hu, Jun Ph.D., NHMFL, Florida State University, Li, Wei Ph.D., University of Tennessee, Memphis TN, Pan, Hong Jun Ph.D., University of Tennessee, Knoxville TN, Wang, Hong Ph.D., Pfizer Global R & D., Wang, Jin-Shan Ph.D., J. S. Research, Inc., Wu, Shaoxiong Ph.D., NMR Center, Emory University.

  • New to this page and siteRadiologia do Esporte (Translated by Google Translator) The Radiology of Sports is a channel of communication between the radiologist specializing Milton Miszputen and ortopedistas / doctors of the sport that refer patients with injuries to perform tests for diagnosis by image. The site aims to increase mutual of specialists with the publication of selected clinical cases of importance for Sports Medicine.

  • SMRT Sites of Interest  Last updated: 09 Feb 2006  (Great Resource) This is a partial list of NMR and MRI resources available on the World Wide Web.  The content of these sites is not controlled or endorsed in any way by the ISMRM or SMRT.  If you have suggestions for additional sites, or one of the listed sites seems no longer functional, please let us know.

  • Upright MRI Publication   This Web site is provided to serve as a research resource in the new field of weight-bearing, upright MRI imaging. It is for informational purposes only and is generally intended for medical professionals and those similarly interested. Created by FONAR Corporation ( and launched in November, 2005, the Web site will be updated continuously.

  • Web Spectra – Problems in NMR and IR Spectroscopy  Welcome to WebSpectra – This site was established to provide chemistry students with a library of spectroscopy problems. Interpretation of spectra is a technique that requires practice – this site provides 1H NMR and 13C NMR, DEPT, COSY and IR spectra of various compounds for students to interpret. Hopefully, these problems will provide a useful resource to better understand spectroscopy. This project is supported by Cambridge Isotope Laboratories and the UCLA Department of Chemistry and Biochemistry.

  • Yale Diagnostic Radiology NMR Home Page  The new Yale MR Research Center  is part of a $176 million dollar research and teaching facility at Yale University School of Medicine.  The imaging facilities include 33,000 square feet of laboratory and imaging space.  This includes dedicated spaces for electrophysiological and psychological testing, for computing, and image and data analysis, and will thus contain all the resources for integrated studies of human brain function. It will house all our research magnets and personnel in one contiguous facility.

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