Role of MRI in diagnosis of mild cognitive impairment, and Alzheimer’s disease

Brain Stories

Diagnosis of mild cognitive impairment(MCI) and Alzheimer’s disease (AD) is generally a clinical diagnosis, but with the aids of Magnetic resonance imaging (MRI), it has great value of sensitivity and specificity with MRI alone reaching more than 90% [ref1]. How MRI help in diagnosis? and what structural images is expected and used in the diagnosis of both MCI and AD? and can they be differentiated based on MRI?

Several autopsy has show that medial temporal lobe is affected earliest in AD and has positive relationship with MRI results [ref2]. From the study provided by The Alzheimer’s Disease Neuroimaging Initiative (ADNI), which is a multi-center study assessing neuroimaging in diagnosis and longitudinal monitoring, has done study on several region of interest, especially medial temporal lobe which include hippocampus and entorhinal cortex. Other region include amygdala, parietal and temporal cortex. In AD and MCI, there is reduction in global gray matter density…

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